Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 16/20 | 0.51 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9941201 | 0.85 | TTK (0.54) | TTKMAPKAPK5 | |
| SCHEMBL9940274 | 0.84 | TTK (0.55) | TTKAURKARPS6KB1HSP90AA1 | |
| SCHEMBL9942386 | 0.83 | TTK (0.49) | TTKAURKARPS6KB1HSP90AA1 | |
| SCHEMBL9940705 | 0.83 | TTK (0.72) | TTK | |
| SCHEMBL9941299 | 0.83 | TTK (0.61) | TTK | |
| SCHEMBL9941302 | 0.83 | TTK (0.43) | TTKAURKARPS6KB1HSP90AA1 | |
| SCHEMBL9940707 | 0.82 | TTK (0.45) | TTKAURKARPS6KB1HSP90AA1 | |
| SCHEMBL9940982 | 0.82 | MAPKAPK5 (0.51) | TTKMAPKAPK5 | |
| SCHEMBL15375677 | 0.82 | TTK (0.60) | TTK | |
| SCHEMBL9942193 | 0.82 | TTK (0.52) | TTKAURKARPS6KB1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651948-A1 | IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS | Bayer Intellectual Property GmbH (DE) | 2013-10-23 | — | — | EP | claimed |
| WO-2012080229-A1 | IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-21 | — | — | WO | claimed |