Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 16/20 | 0.51 |
| ▸ | ACE | P12821 | 8/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9930052 | 0.88 | MME (0.45) | MMEACECTSKMMEL1 | |
| SCHEMBL9929930 | 0.81 | MME (0.56) | MMEMMEL1 | |
| SCHEMBL9941284 | 0.80 | FOLH1 (0.42) | MMEACE | |
| SCHEMBL9929680 | 0.80 | FOLH1 (0.42) | MMEACE | |
| SCHEMBL14890642 | 0.80 | MME (0.69) | MMEACEMMEL1 | |
| SCHEMBL18597877 | 0.80 | MME (0.69) | MMEACEMMEL1 | |
| SCHEMBL15464073 | 0.79 | MME (0.55) | MME | |
| SCHEMBL9929999 | 0.78 | MME (0.66) | MME | |
| SCHEMBL14900576 | 0.78 | MME (0.59) | MMEACEMMEL1 | |
| SCHEMBL15464105 | 0.77 | MME (0.68) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651896-A1 | NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012082853-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-06-21 | — | — | WO | disclosed |