Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 12/20 | 0.47 |
| ▸ | FYN | P06241 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9940987 | 0.83 | TTK (0.49) | TTKMAPKAPK5 | |
| SCHEMBL9941201 | 0.82 | TTK (0.54) | TTKMAPKAPK5 | |
| SCHEMBL9938292 | 0.82 | TTK (0.55) | TTKMAPKAPK5 | |
| SCHEMBL9941127 | 0.82 | TTK (0.53) | TTKMAPKAPK5 | |
| SCHEMBL9941138 | 0.82 | TTK (0.57) | TTKMAPKAPK5 | |
| SCHEMBL9941199 | 0.81 | TTK (0.70) | TTK | |
| SCHEMBL9941237 | 0.81 | TTK (0.49) | TTKMAPKAPK5 | |
| SCHEMBL9940873 | 0.81 | TTK (0.51) | TTKMAPKAPK5 | |
| SCHEMBL12409232 | 0.80 | FYN (0.62) | TTKFYNMAPTSYKTP53 | |
| SCHEMBL9940982 | 0.79 | MAPKAPK5 (0.51) | TTKMAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651948-A1 | IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS | Bayer Intellectual Property GmbH (DE) | 2013-10-23 | — | — | EP | claimed |
| WO-2012080229-A1 | IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-21 | — | — | WO | claimed |