Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 20/20 | 0.66 |
| ▸ | ACE | P12821 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15463769 | 1.00 | MME (0.66) | MMEACE | |
| SCHEMBL18409026 | 0.85 | MME (0.72) | MME | |
| SCHEMBL9929779 | 0.85 | MME (0.66) | MMEACE | |
| SCHEMBL9941361 | 0.85 | MME (0.66) | MMEACE | |
| SCHEMBL15464305 | 0.81 | MME (0.69) | MMEACE | |
| SCHEMBL14890619 | 0.80 | MME (1.00) | MMEACE | |
| SCHEMBL18597765 | 0.80 | MME (1.00) | MMEACE | |
| SCHEMBL9930290 | 0.79 | MME (0.74) | MMEACE | |
| SCHEMBL9929744 | 0.79 | MME (0.62) | MMEACE | |
| SCHEMBL9937046 | 0.79 | MME (0.74) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651896-A1 | NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012082853-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-06-21 | — | — | WO | disclosed |