Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 19/20 | 0.66 |
| ▸ | ACE | P12821 | 6/20 | 0.66 |
| ▸ | EMG1 | Q92979 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9929779 | 1.00 | MME (0.66) | MMEACEEMG1 | |
| SCHEMBL18409026 | 0.91 | MME (0.72) | MME | |
| SCHEMBL11969975 | 0.90 | MME (0.56) | MMEACE | |
| SCHEMBL16930658 | 0.86 | MME (0.56) | MMEACE | |
| SCHEMBL9941314 | 0.85 | MME (0.66) | MMEACE | |
| SCHEMBL15463769 | 0.85 | MME (0.66) | MMEACE | |
| SCHEMBL9929871 | 0.84 | MME (0.71) | MMEACE | |
| SCHEMBL9963915 | 0.83 | MME (0.66) | MMEACEEMG1 | |
| SCHEMBL15467397 | 0.82 | MME (0.63) | MMEACE | |
| SCHEMBL19687925 | 0.82 | MME (0.63) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651896-A1 | NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012082853-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-06-21 | — | — | WO | disclosed |