Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ATF4 | P18848 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9795204 | 1.00 | EPHX2 (0.58) | EPHX2SMN1; SMN2SMYD3KMT2AHPGD | |
| SCHEMBL16853215 | 0.91 | SMN1; SMN2 (0.48) | EPHX2SMN1; SMN2SMYD3KMT2AHPGD | |
| SCHEMBL3135300 | 0.91 | — | — | |
| Hydrochloric Acid SCHEMBL1996186 | 0.89 | — | — | |
| SCHEMBL9795298 | 0.83 | EPHX2 (0.54) | EPHX2SMN1; SMN2SMYD3 | |
| SCHEMBL9499974 | 0.83 | EPHX2 (0.54) | EPHX2SMN1; SMN2SMYD3 | |
| SCHEMBL991938 | 0.82 | SMN1; SMN2 (0.61) | EPHX2SMN1; SMN2KMT2AHPGDEPHX1 | |
| SCHEMBL31723928 | 0.82 | — | — | |
| SCHEMBL12819734 | 0.81 | SMN1; SMN2 (0.41) | EPHX2SMN1; SMN2SMYD3KMT2AHPGD | |
| SCHEMBL991949 | 0.81 | EPHX1 (0.52) | SMN1; SMN2KMT2AEPHX1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454257-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | claimed |
| WO-2011008915-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | claimed |
| EP-2454257-B1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBVIE INC (US) | 2013-08-21 | — | — | EP | disclosed |
| EP-2454257-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008915-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | disclosed |
| US-5037849-A | For treatment of heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1991-08-06 | — | — | US | disclosed |