Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.55 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.50 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9933128 | 1.00 | SLC6A5 (0.57) | SLC6A5EPHX2LPAR1LPAR2ENPP2 | |
| SCHEMBL9933130 | 1.00 | SLC6A5 (0.57) | SLC6A5EPHX2LPAR1LPAR2ENPP2 | |
| SCHEMBL9934475 | 1.00 | SLC6A5 (0.57) | SLC6A5EPHX2LPAR1LPAR2ENPP2 | |
| SCHEMBL9933132 | 1.00 | SLC6A5 (0.57) | SLC6A5EPHX2LPAR1LPAR2ENPP2 | |
| SCHEMBL9934473 | 1.00 | SLC6A5 (0.57) | SLC6A5EPHX2LPAR1LPAR2ENPP2 | |
| SCHEMBL9934468 | 1.00 | SLC6A5 (0.57) | SLC6A5EPHX2LPAR1LPAR2ENPP2 | |
| SCHEMBL9933918 | 0.97 | KDM4E (0.55) | SLC6A5EPHX2KDM4ECNR1ALDH1A1 | |
| SCHEMBL9933913 | 0.97 | KDM4E (0.55) | SLC6A5EPHX2KDM4ECNR1ALDH1A1 | |
| SCHEMBL9933919 | 0.97 | KDM4E (0.55) | SLC6A5EPHX2KDM4ECNR1ALDH1A1 | |
| SCHEMBL9933916 | 0.97 | KDM4E (0.55) | SLC6A5EPHX2KDM4ECNR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2652134-A2 | GALACTOSE CLUSTER-PHARMACOKINETIC MODULATOR TARGETING MOIETY FOR SIRNA | Arrowhead Research Corporation (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012083046-A2 | GALACTOSE CLUSTER-PHARMACOKINETIC MODULATOR TARGETING MOIETY FOR SIRNA | ARROWHEAD RESEARCH CORPORATION (US) | 2012-06-21 | — | — | WO | disclosed |