Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 12/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9940274 | 0.87 | TTK (0.55) | TTKHSP90AA1AURKARPS6KB1 | |
| SCHEMBL9942193 | 0.85 | TTK (0.52) | TTKHSP90AA1LCKPTK6AURKB | |
| SCHEMBL9942710 | 0.85 | TTK (0.49) | TTKLCKPTK6AURKB | |
| SCHEMBL9975027 | 0.84 | TTK (0.71) | TTK | |
| SCHEMBL15675597 | 0.84 | TTK (0.59) | TTK | |
| SCHEMBL9940914 | 0.83 | TTK (0.51) | TTKHSP90AA1AURKARPS6KB1 | |
| SCHEMBL9942416 | 0.74 | TTK (0.48) | TTK | |
| SCHEMBL9940451 | 0.74 | TTK (0.50) | TTKHSP90AA1AURKARPS6KB1 | |
| SCHEMBL9942285 | 0.73 | TTK (0.49) | TTKHSP90AA1AURKARPS6KB1SYK | |
| SCHEMBL9942339 | 0.73 | TTK (0.51) | TTKLCKPTK6AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651945-A1 | 6-SUBSTITUTED IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS | Bayer Intellectual Property GmbH (DE) | 2013-10-23 | — | — | EP | claimed |
| WO-2012080236-A1 | 6-SUBSTITUTED IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-21 | — | — | WO | claimed |