Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | PRKCI | P41743 | 2/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.32 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RHEB | Q15382 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12491412 | 0.82 | DYRK1A (0.47) | AXLPRKCIAHRDYRK1ACCR8 | |
| SCHEMBL2628940 | 0.78 | PRKCI (0.40) | AXLPRKCIAHRDYRK1ACCR8 | |
| SCHEMBL10069068 | 0.76 | NUDT1 (0.38) | AXLPRKCIDYRK1ACCR8JAK2 | |
| SCHEMBL16046354 | 0.74 | AXL (0.41) | AXLPRKCIAHRDYRK1ACCNK | |
| SCHEMBL12491288 | 0.73 | PRKCI (0.42) | AXLPRKCIAHRDYRK1ACCR8 | |
| SCHEMBL10326422 | 0.72 | ABL1 (0.37) | AXLPRKCIJAK2JAK1TYK2 | |
| SCHEMBL9942629 | 0.71 | DYRK1A (0.44) | AXLPRKCIAHRDYRK1ACCR8 | |
| SCHEMBL26145364 | 0.71 | AXL (0.44) | AXLPRKCIAHRDYRK1ACCR8 | |
| SCHEMBL20577529 | 0.71 | PRKCI (0.40) | AXLPRKCIAHRDYRK1ACCR8 | |
| SCHEMBL31000812 | 0.71 | PRKCI (0.40) | AXLPRKCIAHRDYRK1ACCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363705-B9 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2012-11-07 | — | — | EP | disclosed |
| EP-1363705-B1 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2012-06-13 | — | — | EP | disclosed |