Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389693 | 0.85 | CA12 (0.36) | CA12CA9TRPV1WNT3A | |
| SCHEMBL12530352 | 0.72 | CA12 (0.40) | CA12CA9 | |
| SCHEMBL2392961 | 0.72 | S1PR1 (0.38) | CA12CA9 | |
| SCHEMBL9942831 | 0.72 | CA12 (0.38) | CA12CA9 | |
| SCHEMBL9942847 | 0.71 | CA12 (0.40) | CA12CA9 | |
| SCHEMBL9942672 | 0.70 | CA12 (0.41) | CA12CA9 | |
| SCHEMBL9942848 | 0.69 | CA12 (0.35) | CA12CA9 | |
| SCHEMBL9942840 | 0.69 | CA12 (0.38) | CA12CA9WNT3A | |
| SCHEMBL9942843 | 0.67 | DDR1 (0.40) | CA12CA9 | |
| SCHEMBL2387605 | 0.67 | CA12 (0.36) | CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2476671-A1 | 1H-Quinazoline-2,4-diones | Novartis AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| EP-2468732-A1 | 1H-Quinazoline-2,4-diones | Novartis AG (CH) | 2012-06-27 | — | — | EP | disclosed |
| EP-2463278-A1 | 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS | Novartis AG (CH) | 2012-06-13 | — | — | EP | disclosed |