Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 19/20 | 0.61 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL728067 | 0.86 | DHODH (0.79) | DHODH | |
| SCHEMBL9943404 | 0.81 | DHODH (0.58) | DHODHNR4A2 | |
| SCHEMBL3728325 | 0.79 | DHODH (0.67) | DHODHJAK2JAK3 | |
| SCHEMBL729452 | 0.76 | DHODH (1.00) | DHODH | |
| SCHEMBL728088 | 0.74 | DHODH (0.75) | DHODH | |
| SCHEMBL729533 | 0.74 | DHODH (1.00) | DHODH | |
| SCHEMBL290518 | 0.73 | DHODH (0.81) | DHODH | |
| SCHEMBL18109142 | 0.72 | DHODH (0.72) | DHODH | |
| SCHEMBL3873430 | 0.72 | DHODH (0.82) | DHODH | |
| SCHEMBL727910 | 0.72 | DHODH (0.80) | DHODHNR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121614-B1 | AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | ALMIRALL SA (ES) | 2012-06-20 | — | — | EP | disclosed |