Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 5/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9943448 | 0.89 | NR1H2 (0.40) | NR1H2RORCUSP2SMN1; SMN2DDB1 | |
| SCHEMBL28943366 | 0.78 | NR1H2 (0.40) | NR1H2RORCUSP2SMN1; SMN2DDB1 | |
| SCHEMBL29422982 | 0.77 | NR1H2 (0.39) | NR1H2RORCUSP2SMN1; SMN2DDB1 | |
| SCHEMBL29560344 | 0.76 | NR1H2 (0.41) | NR1H2RORCUSP2SMN1; SMN2DDB1 | |
| SCHEMBL700726 | 0.76 | HPGD (0.41) | USP2SMN1; SMN2HPGDDPP4KDM1A | |
| SCHEMBL716216 | 0.76 | HPGD (0.41) | USP2SMN1; SMN2HPGDDPP4KDM1A | |
| SCHEMBL14801889 | 0.75 | NR1H2 (0.34) | NR1H2RORCUSP2SMN1; SMN2MEN1 | |
| SCHEMBL24231705 | 0.75 | NR1H2 (0.42) | NR1H2RORCUSP2SMN1; SMN2DDB1 | |
| SCHEMBL21748741 | 0.75 | NR1H2 (0.42) | NR1H2RORCUSP2SMN1; SMN2DDB1 | |
| SCHEMBL21597767 | 0.75 | NR1H2 (0.42) | NR1H2RORCUSP2SMN1; SMN2DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227460-B1 | THERAPEUTIC OXY-PHENYL-ARYL COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2012-06-20 | — | — | EP | disclosed |