Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 10/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9943449 | 0.89 | NR1H2 (0.40) | NR1H2RORCUSP2SMN1; SMN2DDB1 | |
| SCHEMBL716216 | 0.86 | HPGD (0.41) | USP2SMN1; SMN2HPGD | |
| SCHEMBL700726 | 0.86 | HPGD (0.41) | USP2SMN1; SMN2HPGD | |
| SCHEMBL29560344 | 0.84 | NR1H2 (0.41) | NR1H2RORCUSP2SMN1; SMN2DDB1 | |
| SCHEMBL16728425 | 0.81 | NR1H2 (0.42) | NR1H2RORCUSP2SMN1; SMN2MEN1 | |
| SCHEMBL28943368 | 0.78 | RORC (0.42) | NR1H2RORCUSP2SMN1; SMN2DDB1 | |
| SCHEMBL31088422 | 0.76 | RORC (0.39) | NR1H2RORC | |
| SCHEMBL28604356 | 0.76 | PTPN2 (0.44) | USP2SMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL14801888 | 0.75 | RORC (0.35) | NR1H2RORCUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL14801891 | 0.75 | RORC (0.35) | NR1H2RORCUSP2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227460-B1 | THERAPEUTIC OXY-PHENYL-ARYL COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2012-06-20 | — | — | EP | disclosed |