Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | NOTCH1 | P46531 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 11/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14491044 | 0.91 | GSK3A (0.49) | GSK3ANOTCH1KDM4EALDH1A1HPGD | |
| SCHEMBL6476131 | 0.91 | NOTCH1 (0.48) | GSK3ANOTCH1GSK3BMEN1KMT2A | |
| SCHEMBL5341468 | 0.87 | KDM4E (0.51) | GSK3ANOTCH1KDM4EALDH1A1HPGD | |
| SCHEMBL8559118 | 0.84 | NOTCH1 (0.45) | GSK3ANOTCH1KDM4EALDH1A1HPGD | |
| SCHEMBL4578818 | 0.84 | CETP (0.44) | GSK3ANOTCH1MEN1KMT2ACETP | |
| SCHEMBL713237 | 0.83 | CETP (0.44) | GSK3ANOTCH1MEN1KMT2ACETP | |
| SCHEMBL6483147 | 0.81 | KDM4E (0.52) | GSK3ANOTCH1KDM4EALDH1A1HPGD | |
| SCHEMBL970677 | 0.81 | GSK3A (0.49) | GSK3ANOTCH1KDM4EALDH1A1HPGD | |
| SCHEMBL8142340 | 0.75 | KDM4E (0.48) | GSK3ANOTCH1KDM4EALDH1A1HPGD | |
| SCHEMBL4579894 | 0.73 | CETP (0.41) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453544-A2 | SELF-EMULSIFYING FORMULATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | Pfizer Products Inc. (US) | 2004-09-08 | — | — | EP | claimed |
| EP-0818448-B1 | Cycloalkano-pyridine as CETP inhibitors | BAYER AG (DE) | 2003-11-12 | — | — | EP | claimed |
| EP-1305007-A2 | PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | Pfizer Products Inc. (US) | 2003-05-02 | — | — | EP | claimed |
| US-20030022944-A1 | Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors | PFIZER INC. | 2003-01-30 | — | — | US | claimed |
| WO-2003000295-A2 | SELF-EMULSIFYING FORMULATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-01-03 | — | — | WO | claimed |
| US-20020103225-A1 | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors | BEND RESEARCH INC. | 2002-08-01 | — | — | US | claimed |
| WO-2002011710-A2 | PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-02-14 | — | — | WO | claimed |
| US-6069148-A | ANTICHOLESTEROL AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-05-30 | — | — | US | claimed |
| EP-0818448-A1 | Cycloalkano-pyridine as CETP inhibitors | BAYER AG (DE) | 1998-01-14 | — | — | EP | claimed |
| US-20160374945-A1 | PHARMACEUTICAL COMPOSITIONS OF DISPERSIONS OF DRUG AND NEUTRAL POLYMERS | BEND RESEARCH, INC. (US) | 2016-12-29 | — | — | US | disclosed |
| US-9468604-B2 | Pharmaceutical compositions of dispersions of drug and neutral polymers | BEND RESEARCH, INC. (US) | 2016-10-18 | — | — | US | disclosed |
| EP-2258352-B1 | PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | BEND RES INC (US) | 2015-05-13 | — | — | EP | disclosed |
| US-20140210117-A1 | PHARMACEUTICAL COMPOSITIONS OF DISPERSIONS OF DRUG AND NEUTRAL POLYMERS | BEND RESEARCH, INC. (US) | 2014-07-31 | — | — | US | disclosed |
| EP-2305217-B1 | Method for the preparation of pharmaceutical compositions comprising a solid amorphous dispersion of cholesteryl ester transfer protein inhibitors | BEND RES INC (US) | 2014-07-30 | — | — | EP | disclosed |
| EP-1269994-A2 | Pharmaceutical compositions comprising drug and concentration-enhancing polymers | Pfizer Products Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| US-20020103225-A1 | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors | BEND RESEARCH INC. | 2002-08-01 | — | — | US | disclosed |
| WO-2002011710-A2 | PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-02-14 | — | — | WO | disclosed |
| US-6207671-B1 | FOR TREATMENT OF HYPERTIPOPROTEINAEMIA, ARTERIOSCLEROSIS DYSLIPIDAEMIA | BAYER AKTIENGESELLSCHAFT (DE) | 2001-03-27 | — | — | US | disclosed |
| US-6069148-A | ANTICHOLESTEROL AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-05-30 | — | — | US | disclosed |
| EP-0818448-A1 | Cycloalkano-pyridine as CETP inhibitors | BAYER AG (DE) | 1998-01-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103225-A1 | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors | CETP, HDLBP, NPC1L1 | GSK3A 1939/4885NOTCH1 4733/4885KDM4E 2729/4885 |
| US-20030022944-A1 | Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors | CETP, LCAT, LIPA | GSK3A 3176/4885NOTCH1 3364/4885KDM4E 3183/4885 |
| US-20160374945-A1 | PHARMACEUTICAL COMPOSITIONS OF DISPERSIONS OF DRUG AND NEUTRAL POLYMERS | LIPA, ABCG2, ABCB11 | GSK3A 3137/4885NOTCH1 4849/4885KDM4E 3601/4885 |
| US-20140210117-A1 | PHARMACEUTICAL COMPOSITIONS OF DISPERSIONS OF DRUG AND NEUTRAL POLYMERS | LIPA, ABCG2, ABCB11 | GSK3A 3137/4885NOTCH1 4849/4885KDM4E 3601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.