Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 1/20 | 0.45 |
| ▸ | RARG | P13631 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.44 |
| ▸ | PDE4A | P27815 | 5/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | CPT2 | P23786 | 7/20 | 0.43 |
| ▸ | CPT1A | P50416 | 7/20 | 0.43 |
| ▸ | CPT1B | Q92523 | 7/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9944110 | 0.90 | PDE4A (0.47) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL1458164 | 0.89 | PDE4D (0.47) | RARARARBRARGPDE4DPDE4A | |
| SCHEMBL9944107 | 0.86 | PDE4A (0.54) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL9944105 | 0.83 | RARA (0.47) | RARARARBRARGCPT2CPT1A | |
| SCHEMBL9944235 | 0.82 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL1458110 | 0.81 | PDE4A (0.47) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL9944117 | 0.80 | RARA (0.44) | RARARARBRARGCPT2CPT1A | |
| SCHEMBL9944113 | 0.80 | MAPT (0.47) | RARARARBRARGPDE4DCPT2 | |
| SCHEMBL9944095 | 0.80 | RARA (0.52) | RARARARBRARGCPT2CPT1A | |
| SCHEMBL1458497 | 0.80 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447028-B2 | Therapeutic aryl-amido-aryl compounds and their use | KING'S COLLEGE LONDON (GB) | 2016-09-20 | — | — | US | disclosed |
| US-20160039747-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | KING'S COLLEGE LONDON (GB) | 2016-02-11 | — | — | US | disclosed |
| US-20120149737-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | KING'S COLLEGE LONDON (GB) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149737-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | RARA, RARB, RARG | RARA 1/4885RARB 2/4885RARG 3/4885 |
| US-20160039747-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | RARA, RARB, RARG | RARA 1/4885RARB 2/4885RARG 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.