Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.47 |
| ▸ | MYT1 | Q01538 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20866529 | 0.86 | DPP4 (0.47) | DPP4NOTUMMYT1OPRM1OPRL1 | |
| SCHEMBL12821118 | 0.84 | DPP4 (0.52) | DPP4NOTUMMYT1OPRM1OPRL1 | |
| SCHEMBL19154061 | 0.82 | DPP4 (0.51) | DPP4NOTUMMYT1OPRM1OPRL1 | |
| SCHEMBL19058893 | 0.81 | DPP4 (0.52) | DPP4NOTUMMYT1OPRM1OPRL1 | |
| SCHEMBL15490060 | 0.80 | DPP4 (0.58) | DPP4NOTUMP2RY12 | |
| SCHEMBL14970437 | 0.79 | DPP4 (0.46) | DPP4NOTUMMYT1OPRM1OPRL1 | |
| SCHEMBL19111017 | 0.78 | DPP4 (0.50) | DPP4NOTUMMYT1OPRM1OPRL1 | |
| SCHEMBL19722714 | 0.75 | DPP4 (0.46) | DPP4NOTUMMYT1OPRM1OPRL1 | |
| SCHEMBL16219027 | 0.75 | DPP4 (0.49) | DPP4NOTUMMYT1OPRM1OPRL1 | |
| SCHEMBL9944486 | 0.71 | DPP4 (0.53) | DPP4NOTUMMYT1DPP8GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149683-A1 | SUBSTITUTED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK SHARP & DOHME LLC | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149683-A1 | SUBSTITUTED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES | DPP4, DPP3, DPP7 | DPP4 1/4885NOTUM 402/4885MYT1 3353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.