Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | MYT1 | Q01538 | 3/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | WEE1 | P30291 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9944479 | 0.86 | DPP4 (0.49) | DPP4NOTUMOPRM1MYT1OPRL1 | |
| SCHEMBL19154061 | 0.86 | DPP4 (0.51) | DPP4NOTUMOPRM1MYT1OPRL1 | |
| SCHEMBL12821118 | 0.81 | DPP4 (0.52) | DPP4NOTUMOPRM1MYT1OPRL1 | |
| SCHEMBL19111017 | 0.81 | DPP4 (0.50) | DPP4NOTUMOPRM1MYT1OPRL1 | |
| SCHEMBL19058893 | 0.79 | DPP4 (0.52) | DPP4NOTUMOPRM1MYT1OPRL1 | |
| SCHEMBL15490060 | 0.78 | DPP4 (0.58) | DPP4NOTUMALDH1A1KMT2APOLB | |
| SCHEMBL14970437 | 0.76 | DPP4 (0.46) | DPP4NOTUMOPRM1MYT1OPRL1 | |
| SCHEMBL19722714 | 0.73 | DPP4 (0.46) | DPP4NOTUMOPRM1MYT1OPRL1 | |
| SCHEMBL9944468 | 0.73 | SLC2A1 (0.35) | DPP4NOTUM | |
| SCHEMBL16219027 | 0.73 | DPP4 (0.49) | DPP4NOTUMOPRM1MYT1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190100497-A1 | 3-(CARBOXYETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2019-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190100497-A1 | 3-(CARBOXYETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | OPRK1, OPRD1, PKD2 | DPP4 116/4885NOTUM 3631/4885OPRM1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.