Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 15/20 | 0.62 |
| ▸ | BRD4 | O60885 | 7/20 | 0.62 |
| ▸ | BRDT | Q58F21 | 5/20 | 0.62 |
| ▸ | TAF1 | P21675 | 2/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.55 |
| ▸ | RAD52 | P43351 | 1/20 | 0.54 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.52 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.52 |
| ▸ | PDXK | O00764 | 1/20 | 0.52 |
| ▸ | WEE1 | P30291 | 1/20 | 0.52 |
| ▸ | NEK3 | P51956 | 1/20 | 0.52 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.52 |
| ▸ | NEK4 | P51957 | 1/20 | 0.52 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2397662 | 0.94 | PLK1 (0.70) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL9945408 | 0.91 | PLK1 (0.63) | PLK1BRD4BRDTTAF1ALK | |
| SCHEMBL2396519 | 0.90 | PLK1 (0.71) | PLK1BRD4BRDTTAF1ALK | |
| SCHEMBL2396512 | 0.90 | PLK1 (0.71) | PLK1BRD4BRDTTAF1ALK | |
| SCHEMBL2399437 | 0.89 | PLK1 (0.76) | PLK1BRD4BRDTTAF1ALK | |
| SCHEMBL2398538 | 0.88 | PLK1 (0.75) | PLK1BRD4BRDTTAF1ALK | |
| SCHEMBL2397009 | 0.87 | PLK1 (0.60) | PLK1BRD4BRDTTAF1ALK | |
| SCHEMBL2396772 | 0.86 | PLK1 (0.69) | PLK1BRD4BRDTRAD52PLK3 | |
| SCHEMBL2398513 | 0.86 | PLK1 (0.75) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL2399311 | 0.86 | PLK1 (0.79) | PLK1BRD4BRDTRAD52PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120271045-A1 | METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-25 | — | — | US | disclosed |
| US-20120271045-A1 | METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-25 | — | — | US | disclosed |
| US-20120149898-A1 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120149898-A1 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120271045-A1 | METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | DCK, MAP3K5, MAP3K1 | PLK1 42/4885BRD4 1592/4885BRDT 1490/4885 |
| US-20120149898-A1 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K5, MAP4K2 | PLK1 89/4885BRD4 536/4885BRDT 833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.