Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9945847 | 1.00 | SIGMAR1 (0.64) | SIGMAR1HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL12998415 | 1.00 | SIGMAR1 (0.64) | SIGMAR1HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL12998408 | 1.00 | SIGMAR1 (0.64) | SIGMAR1HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL16687762 | 0.82 | HTR2A (0.65) | SIGMAR1HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL11881965 | 0.80 | SIGMAR1 (0.66) | SIGMAR1HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL9903945 | 0.78 | SIGMAR1 (1.00) | SIGMAR1HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL30584623 | 0.78 | SIGMAR1 (1.00) | SIGMAR1HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL12998412 | 0.78 | SIGMAR1 (1.00) | SIGMAR1HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL299351 | 0.78 | SIGMAR1 (1.00) | SIGMAR1HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL299296 | 0.78 | SIGMAR1 (1.00) | SIGMAR1HTR2AHTR2CHTR2BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | HTR2C, GRK2, GRK3 | SIGMAR1 1254/4885HTR2A 7/4885HTR2C 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.