Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9945978 | 0.85 | CYP1A2 (0.39) | CYP1A2CYP2C9CYP2C19L3MBTL1SMN1; SMN2 | |
| SCHEMBL13025543 | 0.83 | ESR1 (0.38) | ESR1CYP1A2CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL14211796 | 0.81 | CYP2C19 (0.43) | ESR1CYP1A2CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL18364567 | 0.80 | CYP1A2 (0.42) | ESR1CYP1A2CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL13025542 | 0.79 | MAPT (0.37) | ESR1L3MBTL1ALDH1A1LMNAKDM4E | |
| SCHEMBL15120786 | 0.78 | CYP1A2 (0.50) | ESR1CYP1A2CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL18374607 | 0.78 | CYP1A2 (0.41) | ESR1CYP1A2CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL14211797 | 0.76 | L3MBTL1 (0.43) | ESR1CYP1A2CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL16852418 | 0.75 | CYP1A2 (0.39) | ESR1CYP1A2CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL24661358 | 0.75 | CYP1A2 (0.47) | ESR1CYP1A2CYP2C9CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | HTR2C, GRK2, GRK3 | ESR1 929/4885CYP1A2 2891/4885CYP2C9 4298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.