Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | GLRA1 | P23415 | 2/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2553915 | 0.80 | GLRA1 (0.46) | GLRA1ALOX15TSHRGABRA1GABRG2 | |
| SCHEMBL12279053 | 0.75 | RXRA (0.72) | IDO1RXRARXRBMRGPRX4HRH3 | |
| SCHEMBL13160063 | 0.75 | RXRA (0.72) | IDO1RXRARXRBMRGPRX4HRH3 | |
| SCHEMBL9261857 | 0.74 | GLRA1 (0.53) | GLRA1TSHRALDH1A1L3MBTL1MAOA | |
| SCHEMBL11112611 | 0.74 | TSHR (0.47) | GLRA1ALOX15TSHRKMT2AL3MBTL1 | |
| SCHEMBL13408054 | 0.74 | TSHR (0.47) | ALOX15TSHRGABRA1GABRG2GABRB3 | |
| SCHEMBL19501401 | 0.74 | IDO1 (0.55) | IDO1RXRARXRBMRGPRX4NFE2L2 | |
| SCHEMBL11951639 | 0.74 | RXRA (0.66) | IDO1RXRARXRBMRGPRX4HRH3 | |
| SCHEMBL24961798 | 0.72 | IDO1 (0.49) | IDO1RXRARXRBALDH1A1KMT2A | |
| SCHEMBL8406586 | 0.72 | GLRA1 (0.51) | GLRA1TSHRALDH1A1L3MBTL1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | HTR2C, GRK2, GRK3 | IDO1 2748/4885GLRA1 1844/4885RXRA 1479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.