Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | MGLL | Q99685 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | AGXT | P21549 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 5/20 | 0.42 |
| ▸ | CA12 | O43570 | 4/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10343480 | 0.83 | KDM4E (0.71) | KDM4ETDP1MGLLHSD17B10LOXL2 | |
| SCHEMBL16633354 | 0.78 | KDM4E (0.77) | KDM4ETDP1MGLLHSD17B10LOXL2 | |
| SCHEMBL147973 | 0.78 | KDM4E (1.00) | KDM4ETDP1MGLLHSD17B10LOXL2 | |
| Naphthalene SCHEMBL29205373 | 0.77 | KDM4E (0.96) | KDM4ETDP1MGLLHSD17B10LOXL2 | |
| SCHEMBL22684755 | 0.74 | KDM4E (0.79) | KDM4ETDP1MGLLHSD17B10LOXL2 | |
| SCHEMBL7742612 | 0.72 | KDM4E (0.67) | KDM4ETDP1MGLLHSD17B10LOXL2 | |
| SCHEMBL14216537 | 0.71 | KDM4E (0.65) | KDM4ETDP1MGLLHSD17B10LOXL2 | |
| SCHEMBL12264 | 0.70 | KDM4E (0.48) | KDM4ETDP1MGLLHSD17B10LOXL2 | |
| SCHEMBL29670757 | 0.70 | KDM4E (0.48) | KDM4ETDP1MGLLHSD17B10LOXL2 | |
| SCHEMBL28329255 | 0.70 | KDM4E (0.48) | KDM4ETDP1MGLLHSD17B10LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | HTR2C, GRK2, GRK3 | KDM4E 4270/4885TDP1 3577/4885MGLL 2486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.