Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8742402 | 0.85 | KMT2A (0.47) | SLC6A2SLC6A3MEN1CYP1A2CYP2C19 | |
| SCHEMBL6830505 | 0.84 | TSHR (0.50) | SLC6A2SLC6A4SLC6A3TSHRTACR1 | |
| SCHEMBL28631602 | 0.79 | TSHR (0.52) | SLC6A2SLC6A4SLC6A3TSHRIDO1 | |
| SCHEMBL790660 | 0.78 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3TSHRCHRNB2 | |
| SCHEMBL29277743 | 0.77 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3TSHRCHRNB2 | |
| SCHEMBL29277741 | 0.77 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3TSHRCHRNB2 | |
| SCHEMBL11100946 | 0.77 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3TSHRCHRNB2 | |
| SCHEMBL10431978 | 0.77 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3TSHRCHRNB2 | |
| SCHEMBL360511 | 0.76 | TSHR (0.48) | SLC6A2SLC6A4SLC6A3TSHRIDO1 | |
| SCHEMBL7563457 | 0.76 | L3MBTL1 (0.42) | SLC6A2SLC6A4SLC6A3TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114890896-B | Dendritic (methyl) acrylic ester monomer and preparation method and application thereof | 中国科学院理化技术研究所 | 2023-07-07 | — | — | CN | disclosed |
| CN-114890896-A | Dendritic (methyl) acrylate monomer and preparation method and application thereof | 中国科学院理化技术研究所 | 2022-08-12 | — | — | CN | disclosed |
| EP-3103791-B1 | 4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-01-31 | — | — | EP | disclosed |
| CN-101610995-B | Glucagon receptor antagonists | 症变治疗公司 | 2017-08-08 | — | — | CN | disclosed |
| EP-3103791-A1 | 4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-12-14 | — | — | EP | disclosed |
| CN-102838460-B | Skin whitening (blast) series of compounds | 尤尼根公司 | 2016-08-03 | — | — | CN | disclosed |
| EP-2170076-B1 | 4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-05-18 | — | — | EP | disclosed |
| US-9096559-B2 | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-08-04 | — | — | US | disclosed |
| US-20130137690-A1 | 4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK SHARP & DOHME LLC | 2013-05-30 | — | — | US | disclosed |
| US-8389553-B2 | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-03-05 | — | — | US | disclosed |
| WO-2000049022-A2 | ORGANOSILICON COMPOUNDS AND USES THEREOF | NORTHWESTERN UNIVERSITY (US) | 2000-08-24 | — | — | WO | disclosed |
| WO-2000025788-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |
| WO-2000014083-A1 | SUBSTITUTED η-PHENYL-Δ-LACTONES AND ANALOGS THEREOF AND USES RELATED THERETO | INFLAZYME PHARMACEUTICALS LTD. (CA) | 2000-03-16 | — | — | WO | disclosed |
| EP-0958293-A1 | NANOMOLAR, NON-PEPTIDE INHIBITORS OF CATHEPSIN D | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998033795-A1 | NANOMOLAR, NON-PEPTIDE INHIBITORS OF CATHEPSIN D | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-08-06 | — | — | WO | disclosed |
| US-5733882-A | Retroviral protease inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-31 | — | — | US | disclosed |
| EP-0602069-A4 | RETROVIRAL PROTEASE INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-05-03 | — | — | EP | disclosed |
| EP-0602069-A1 | RETROVIRAL PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-06-22 | — | — | EP | disclosed |
| CN-1077192-A | The 2-oxoquinoline derivatives | MERCK PATENT GMBH (DE) | 1993-10-13 | — | — | CN | disclosed |
| EP-0487270-A2 | HIV protease inhibitors having polyether substituents | MERCK & CO. INC. (US) | 1992-05-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137690-A1 | 4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | BRDT, HDAC4, HDAC5 | SLC6A2 3814/4885SLC6A4 3283/4885SLC6A3 3824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.