Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 9/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9947656 | 0.89 | PTGER4 (0.68) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL14431117 | 0.89 | PTGER4 (0.46) | PTGER4CYP1A2CYP2D6AKR1B1MEN1 | |
| SCHEMBL9947604 | 0.88 | PTGER4 (0.52) | PTGER4CYP1A2CYP2D6AKR1B1MEN1 | |
| SCHEMBL9948068 | 0.87 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6PPARGPPARD | |
| SCHEMBL10058500 | 0.84 | PTGER4 (0.48) | PTGER4CYP1A2CYP2D6MEN1KMT2A | |
| SCHEMBL1590562 | 0.82 | PTGER4 (0.55) | PTGER4CYP1A2CYP2D6AKR1B1MEN1 | |
| SCHEMBL4611730 | 0.82 | PTGER4 (0.74) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL8591107 | 0.81 | PTGER4 (0.57) | PTGER4CYP1A2CYP2D6AKR1B1MEN1 | |
| SCHEMBL9947957 | 0.81 | PTGER4 (0.59) | PTGER4CYP1A2CYP2D6MEN1KMT2A | |
| SCHEMBL12002249 | 0.81 | PTGER4 (0.45) | PTGER4CYP1A2CYP2D6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979317-B1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LTD (GB) | 2012-08-22 | — | — | EP | disclosed |
| US-8207213-B2 | Benzoisoindole derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2012-06-26 | — | — | US | disclosed |