Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 15/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 15/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9948794 | 0.95 | HCRTR1 (0.39) | HCRTR1HCRTR2CES2PIK3CA | |
| SCHEMBL12700478 | 0.95 | HCRTR1 (0.39) | HCRTR1HCRTR2CES2PIK3CAMTOR | |
| SCHEMBL9948691 | 0.94 | HCRTR1 (0.39) | HCRTR1HCRTR2CES2PIK3CA | |
| SCHEMBL9949233 | 0.89 | HCRTR1 (0.46) | HCRTR1HCRTR2CES2 | |
| SCHEMBL9949086 | 0.89 | HCRTR1 (0.51) | HCRTR1HCRTR2 | |
| SCHEMBL9949057 | 0.89 | HCRTR1 (0.41) | HCRTR1HCRTR2CES2 | |
| SCHEMBL2131217 | 0.86 | HCRTR1 (0.60) | HCRTR1HCRTR2 | |
| SCHEMBL9948490 | 0.85 | HCRTR1 (0.57) | HCRTR1HCRTR2CES2PIK3CA | |
| SCHEMBL9949879 | 0.85 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL9949771 | 0.85 | SLC6A2 (0.43) | HCRTR1HCRTR2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165331-A1 | Di/tri-aza-spiro-C9-C11alkanes | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-06-28 | — | — | US | claimed |
| WO-2012101487-A1 | DI/TRI-AZA-SPIRO-C9-C11ALKANES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| US-20120165331-A1 | Di/tri-aza-spiro-C9-C11alkanes | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-06-28 | — | — | US | disclosed |
| US-20120165331-A1 | Di/tri-aza-spiro-C9-C11alkanes | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-06-28 | — | — | US | disclosed |
| US-20120165331-A1 | Di/tri-aza-spiro-C9-C11alkanes | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165331-A1 | Di/tri-aza-spiro-C9-C11alkanes | TACR2, TACR1, AGTR1 | HCRTR1 593/4885HCRTR2 607/4885CES2 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.