Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2352519 | 0.80 | PNP (0.43) | PNPALDH1A1GDAMEN1KMT2A | |
| SCHEMBL28648090 | 0.77 | PNP (0.44) | PNPALDH1A1GDAMEN1KMT2A | |
| SCHEMBL13007561 | 0.77 | PNP (0.41) | PNPALDH1A1GDAMEN1KMT2A | |
| SCHEMBL2837687 | 0.77 | PNP (0.41) | PNPALDH1A1GDAMEN1KMT2A | |
| SCHEMBL4560085 | 0.77 | GDA (0.53) | PNPALDH1A1GDAMEN1KMT2A | |
| SCHEMBL8356642 | 0.77 | PNP (0.41) | PNPALDH1A1GDAMEN1KMT2A | |
| SCHEMBL618978 | 0.77 | PNP (0.44) | PNPALDH1A1GDAMEN1KMT2A | |
| SCHEMBL133948 | 0.77 | PNP (0.41) | PNPALDH1A1GDAMEN1KMT2A | |
| SCHEMBL10998 | 0.77 | GDA (0.53) | PNPALDH1A1GDAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7296125 | 0.76 | PNP (0.40) | PNPALDH1A1GDAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105936634-B | A kind of synthetic method of Li Gelieting | 赤峰赛林泰药业有限公司 | 2018-05-25 | — | — | CN | claimed |
| CN-105073749-A | Improved process for the preparation of linagliptin | MYLAN LAB LTD | 2015-11-18 | — | — | CN | claimed |
| EP-2935266-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF LINAGLIPTIN | Mylan Laboratories Ltd. (IN) | 2015-10-28 | — | — | EP | claimed |
| US-20150299200-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF LINAGLIPTIN | MYLAN LABORATORIES LTD (IN) | 2015-10-22 | — | — | US | claimed |
| WO-2014097314-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF LINAGLIPTIN | MYLAN LABORATORIES LTD (IN) | 2014-06-26 | — | — | WO | claimed |
| CN-105936634-B | A kind of synthetic method of Li Gelieting | 赤峰赛林泰药业有限公司 | 2018-05-25 | — | — | CN | disclosed |
| CN-105936634-B | A kind of synthetic method of Li Gelieting | 赤峰赛林泰药业有限公司 | 2018-05-25 | — | — | CN | disclosed |
| US-20160304520-A1 | An improved process for preparing Linagliptin and its key Intermediates | WOCKHARDT LTD (IN) | 2016-10-20 | — | — | US | disclosed |
| CN-105936634-A | Synthetic method of linagliptin | 赤峰赛林泰药业有限公司 | 2016-09-14 | — | — | CN | disclosed |
| CN-105073749-A | Improved process for the preparation of linagliptin | MYLAN LAB LTD | 2015-11-18 | — | — | CN | disclosed |
| EP-2935266-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF LINAGLIPTIN | Mylan Laboratories Ltd. (IN) | 2015-10-28 | — | — | EP | disclosed |
| US-20150299200-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF LINAGLIPTIN | MYLAN LABORATORIES LTD (IN) | 2015-10-22 | — | — | US | disclosed |
| WO-2015011609-A1 | PROCESS FOR THE PREPARATION OF LINAGLIPTIN AND AN INTERMEDIATE THEREOF | RANBAXY LABORATORIES LIMITED (IN) | 2015-01-29 | — | — | WO | disclosed |
| WO-2015004599-A1 | AN IMPROVED PROCESS FOR PREPARING LINAGLIPTIN AND ITS KEY INTERMEDIATES | WOCKHARDT LIMITED (IN) | 2015-01-15 | — | — | WO | disclosed |
| WO-2014097314-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF LINAGLIPTIN | MYLAN LABORATORIES LTD (IN) | 2014-06-26 | — | — | WO | disclosed |
| US-20120165525-A1 | PROCESS FOR THE PREPARATION OF LINAGLIPTIN | DIPHARMA FRANCIS S.R.L. (IT) | 2012-06-28 | — | — | US | disclosed |
| EP-2468749-A1 | Process for the preparation of Linagliptin | Dipharma Francis S.r.l. (IT) | 2012-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165525-A1 | PROCESS FOR THE PREPARATION OF LINAGLIPTIN | DPP4, DPP8, DPP7 | PNP 21/4885ALDH1A1 538/4885GDA 653/4885 |
| US-20160304520-A1 | An improved process for preparing Linagliptin and its key Intermediates | DPP4, LCT, DPP3 | PNP 166/4885ALDH1A1 545/4885GDA 1939/4885 |
| US-20150299200-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF LINAGLIPTIN | DPP4, DPP3, DPP8 | PNP 83/4885ALDH1A1 1528/4885GDA 907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.