Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 20/20 | 0.59 |
| ▸ | HCRTR1 | O43613 | 19/20 | 0.57 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9950392 | 0.89 | HCRTR2 (0.55) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL9951194 | 0.88 | HCRTR2 (0.55) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL10189120 | 0.88 | HCRTR2 (0.59) | HCRTR2HCRTR1CYP2C8CYP2C19KCNH2 | |
| SCHEMBL9951038 | 0.87 | HCRTR2 (0.60) | HCRTR2HCRTR1CYP2C8CYP2C19KCNH2 | |
| SCHEMBL10188821 | 0.80 | CCR5 (0.37) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL10241695 | 0.80 | HCRTR2 (0.40) | HCRTR2HCRTR1CYP2C8CYP2C19 | |
| SCHEMBL10189139 | 0.80 | HCRTR1 (0.51) | HCRTR2HCRTR1 | |
| SCHEMBL9950683 | 0.79 | HCRTR2 (0.61) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL9949995 | 0.77 | HCRTR2 (0.62) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL9950544 | 0.77 | HCRTR2 (0.56) | HCRTR2HCRTR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165339-A1 | CYCLOPROPANE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-06-28 | — | — | US | claimed |
| US-20120165339-A1 | CYCLOPROPANE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-06-28 | — | — | US | disclosed |
| US-20120165339-A1 | CYCLOPROPANE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165339-A1 | CYCLOPROPANE DERIVATIVES | HCRTR2, HCRTR1, CNR1 | HCRTR2 1/4885HCRTR1 2/4885CYP2C8 2398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.