Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.69 |
| ▸ | INSR | P06213 | 4/20 | 0.66 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 3/20 | 0.54 |
| ▸ | PAK4 | O96013 | 2/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.54 |
| ▸ | CSF1R | P07333 | 2/20 | 0.54 |
| ▸ | LYN | P07948 | 2/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.54 |
| ▸ | MARK3 | P27448 | 2/20 | 0.54 |
| ▸ | FLT4 | P35916 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.54 |
| ▸ | BLK | P51451 | 2/20 | 0.54 |
| ▸ | NEK2 | P51955 | 2/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.54 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9950721 | 1.00 | IGF1R (0.69) | IGF1RKCNH2INSRPKN1LCK | |
| SCHEMBL1442870 | 0.95 | IGF1R (0.77) | IGF1RKCNH2INSRPKN1LCK | |
| SCHEMBL1443738 | 0.95 | IGF1R (0.77) | IGF1RKCNH2INSRPKN1LCK | |
| SCHEMBL1442875 | 0.95 | IGF1R (0.77) | IGF1RKCNH2INSRPKN1LCK | |
| SCHEMBL1442869 | 0.95 | IGF1R (0.77) | IGF1RKCNH2INSRPKN1LCK | |
| SCHEMBL1442872 | 0.90 | IGF1R (0.75) | IGF1RKCNH2INSRPKN1LCK | |
| SCHEMBL1442871 | 0.90 | IGF1R (0.75) | IGF1RKCNH2INSRPKN1LCK | |
| SCHEMBL9950194 | 0.88 | IGF1R (0.79) | IGF1RKCNH2INSRPKN1LCK | |
| SCHEMBL9950191 | 0.88 | IGF1R (0.79) | IGF1RKCNH2INSRPKN1LCK | |
| SCHEMBL9950205 | 0.86 | IGF1R (0.71) | IGF1RKCNH2INSRPKN1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475668-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | Novartis AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | NOVARTIS AG (CH) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | ETV6, CYP11B2, CYP11B1 | IGF1R 2735/4885KCNH2 3657/4885INSR 695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.