Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 16/20 | 0.71 |
| ▸ | INSR | P06213 | 5/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.70 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.70 |
| ▸ | LCK | P06239 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.57 |
| ▸ | LYN | P07948 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | PAK4 | O96013 | 1/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.57 |
| ▸ | MARK3 | P27448 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.57 |
| ▸ | BLK | P51451 | 1/20 | 0.57 |
| ▸ | NEK2 | P51955 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1442605 | 1.00 | IGF1R (0.71) | IGF1RINSRKCNH2PKN1LCK | |
| SCHEMBL9950271 | 1.00 | IGF1R (0.71) | IGF1RINSRKCNH2PKN1LCK | |
| SCHEMBL9951211 | 1.00 | IGF1R (0.71) | IGF1RINSRKCNH2PKN1LCK | |
| SCHEMBL1442604 | 1.00 | IGF1R (0.71) | IGF1RINSRKCNH2PKN1LCK | |
| SCHEMBL9951186 | 0.92 | IGF1R (0.72) | IGF1RINSRKCNH2PKN1LCK | |
| SCHEMBL9949816 | 0.92 | IGF1R (0.72) | IGF1RINSRKCNH2PKN1LCK | |
| SCHEMBL9949820 | 0.92 | IGF1R (0.72) | IGF1RINSRKCNH2PKN1LCK | |
| SCHEMBL9949824 | 0.92 | IGF1R (0.72) | IGF1RINSRKCNH2PKN1LCK | |
| SCHEMBL9951184 | 0.92 | IGF1R (0.72) | IGF1RINSRKCNH2PKN1LCK | |
| SCHEMBL9951003 | 0.90 | IGF1R (0.72) | IGF1RINSRKCNH2PKN1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | NOVARTIS AG (CH) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | ETV6, CYP11B2, CYP11B1 | IGF1R 2735/4885INSR 695/4885KCNH2 3657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.