Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | HTT | P42858 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.61 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.60 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12835410 | 0.86 | GRM4 (0.64) | TMPRSS4MEN1KMT2AHTTKDM4E | |
| SCHEMBL18804918 | 0.85 | GRM4 (0.63) | TMPRSS4MEN1KMT2AHTTKDM4E | |
| SCHEMBL17154495 | 0.85 | GRM4 (0.63) | TMPRSS4MEN1KMT2AHTTLMNA | |
| SCHEMBL5665935 | 0.85 | FADS1 (0.66) | TMPRSS4MEN1KMT2AHTTLMNA | |
| SCHEMBL330128 | 0.85 | TMPRSS4 (1.00) | TMPRSS4MEN1KMT2AKDRP2RX1 | |
| SCHEMBL22339323 | 0.85 | TMPRSS4 (0.64) | TMPRSS4MEN1KMT2AHTTKDM4E | |
| SCHEMBL8855725 | 0.84 | GRM4 (0.62) | TMPRSS4MEN1KMT2AHTTKDM4E | |
| SCHEMBL330566 | 0.83 | TMPRSS4 (0.77) | TMPRSS4MEN1KMT2AHTTKDM4E | |
| SCHEMBL330383 | 0.83 | TMPRSS4 (0.77) | TMPRSS4MEN1KMT2AHTTLMNA | |
| SCHEMBL28093056 | 0.83 | PTGS1 (0.72) | MEN1KMT2AHTTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106432137-B | Histone acetyltransferase modulators and uses thereof | 纽约市哥伦比亚大学理事会 | 2020-11-06 | — | — | CN | disclosed |
| EP-3323813-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | UNIV COLUMBIA (US) | 2020-08-26 | — | — | EP | disclosed |
| EP-3323813-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | UNIV COLUMBIA (US) | 2020-08-26 | — | — | EP | disclosed |
| US-20180244603-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2018-08-30 | — | — | US | disclosed |
| EP-3323813-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2018-05-23 | — | — | EP | disclosed |
| EP-3323813-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2018-05-23 | — | — | EP | disclosed |
| US-9969677-B2 | Histone acetyltransferase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-15 | — | — | US | disclosed |
| US-9969677-B2 | Histone acetyltransferase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-15 | — | — | US | disclosed |
| US-9969677-B2 | Histone acetyltransferase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-15 | — | — | US | disclosed |
| EP-2654428-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | UNIV COLUMBIA (US) | 2018-02-14 | — | — | EP | disclosed |
| US-20170121276-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-05-04 | — | — | US | disclosed |
| CN-106432137-A | Histone acetyltransferase modulators and uses thereof | 纽约市哥伦比亚大学理事会 | 2017-02-22 | — | — | CN | disclosed |
| CN-103347392-B | Histone acetyltransferase modulators and uses thereof | 纽约市哥伦比亚大学理事会 | 2016-10-12 | — | — | CN | disclosed |
| US-20150210717-A1 | SPECIFIC INHIBITORS OF PROTEIN P21 AS THERAPEUTIC AGENTS | LEIBNIZ-INSTITUT FÜR ALTERSFORSCHUNG (DE) | 2015-07-30 | — | — | US | disclosed |
| WO-2014041125-A1 | SPECIFIC INHIBITORS OF PROTEIN P21 AS THERAPEUTIC AGENTS | BADEN-WÜRTTEMBERG STIFTUNG GMBH (DE) | 2014-03-20 | — | — | WO | disclosed |
| EP-2654428-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | The Trustees of Columbia University in the City of New York (US) | 2013-10-30 | — | — | EP | disclosed |
| CN-103347392-A | Histone acetyltransferase modulators and uses thereof | UNIV COLUMBIA | 2013-10-09 | — | — | CN | disclosed |
| WO-2012088420-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012088420-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-06-28 | — | — | WO | disclosed |
| CN-102276500-A | Salicylamide antineoplastic compounds, synthesizing method thereof, and purpose thereof | — | 2011-12-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180244603-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | EP300, HTT, KAT2A | TMPRSS4 2854/4885MEN1 2622/4885KMT2A 50/4885 |
| US-20170121276-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | EP300, KAT2A, HTT | TMPRSS4 2804/4885MEN1 2596/4885KMT2A 51/4885 |
| US-20150210717-A1 | SPECIFIC INHIBITORS OF PROTEIN P21 AS THERAPEUTIC AGENTS | CDKN1A, ING2, BCCIP | TMPRSS4 3989/4885MEN1 2917/4885KMT2A 2523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.