Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CCR9 | P51686 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18814827 | 0.88 | AR (0.49) | ARALDH1A1CCR9HPGDKMT2A | |
| SCHEMBL9952072 | 0.87 | GALR3 (0.43) | ARALDH1A1CCR9HPGDKMT2A | |
| SCHEMBL19807215 | 0.87 | AR (0.43) | ARALDH1A1CCR9HPGDKMT2A | |
| SCHEMBL18804922 | 0.82 | TYMS (0.52) | ARCCR9KMT2AMEN1DPP4 | |
| SCHEMBL17144792 | 0.81 | KMT2A (0.47) | ALDH1A1HPGDKMT2AKDM4EMEN1 | |
| SCHEMBL10067176 | 0.80 | HTR2A (0.42) | ARALDH1A1KDM4EGAAMAPT | |
| SCHEMBL9952239 | 0.79 | CCR9 (0.48) | ARALDH1A1CCR9KMT2AKDM4E | |
| SCHEMBL19805573 | 0.79 | HTR2C (0.47) | ARALDH1A1GAADPP4MAPT | |
| SCHEMBL10066977 | 0.78 | AR (0.55) | ARCCR9KMT2AMEN1 | |
| SCHEMBL13265370 | 0.76 | ADORA2A (0.61) | ALDH1A1HPGDKMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230165813-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2023-06-01 | — | — | US | disclosed |
| US-20200330410-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2020-10-22 | — | — | US | disclosed |
| EP-3323813-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | UNIV COLUMBIA (US) | 2020-08-26 | — | — | EP | disclosed |
| EP-3323813-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | UNIV COLUMBIA (US) | 2020-08-26 | — | — | EP | disclosed |
| US-10653648-B2 | Histone acetyltransferase activators and compositions and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-05-19 | — | — | US | disclosed |
| US-20180244603-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2018-08-30 | — | — | US | disclosed |
| EP-3323813-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2018-05-23 | — | — | EP | disclosed |
| EP-3323813-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2018-05-23 | — | — | EP | disclosed |
| US-9969677-B2 | Histone acetyltransferase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-15 | — | — | US | disclosed |
| US-9969677-B2 | Histone acetyltransferase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-15 | — | — | US | disclosed |
| EP-2654428-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | UNIV COLUMBIA (US) | 2018-02-14 | — | — | EP | disclosed |
| US-20180021273-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-01-25 | — | — | US | disclosed |
| WO-2018017858-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-01-25 | — | — | WO | disclosed |
| US-20170121276-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-05-04 | — | — | US | disclosed |
| US-20170121276-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-05-04 | — | — | US | disclosed |
| EP-2654428-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | The Trustees of Columbia University in the City of New York (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012088420-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012088420-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180021273-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | AR 785/4885ALDH1A1 3075/4885CCR9 4540/4885 |
| US-20180244603-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | EP300, HTT, KAT2A | AR 964/4885ALDH1A1 2027/4885CCR9 4735/4885 |
| US-20170121276-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | EP300, KAT2A, HTT | AR 892/4885ALDH1A1 2114/4885CCR9 4738/4885 |
| US-20200330410-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | AR 785/4885ALDH1A1 3075/4885CCR9 4540/4885 |
| US-10653648-B2 | Histone acetyltransferase activators and compositions and uses thereof | HDAC6, HDAC9, HDAC5 | AR 785/4885ALDH1A1 3075/4885CCR9 4540/4885 |
| US-20230165813-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | AR 785/4885ALDH1A1 3075/4885CCR9 4540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.