Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 13/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | INSR | P06213 | 5/20 | 0.69 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.69 |
| ▸ | RET | P07949 | 10/20 | 0.66 |
| ▸ | KIF5B | P33176 | 7/20 | 0.66 |
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.59 |
| ▸ | LYN | P07948 | 3/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.55 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | LATS1 | O95835 | 1/20 | 0.55 |
| ▸ | YES1 | P07947 | 1/20 | 0.55 |
| ▸ | HCK | P08631 | 1/20 | 0.55 |
| ▸ | FECH | P22830 | 1/20 | 0.55 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.55 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9951640 | 1.00 | IGF1R (1.00) | IGF1RKCNH2INSRPKN1RET | |
| SCHEMBL1441566 | 1.00 | IGF1R (1.00) | IGF1RKCNH2INSRPKN1RET | |
| SCHEMBL1441569 | 1.00 | IGF1R (1.00) | IGF1RKCNH2INSRPKN1RET | |
| SCHEMBL9950585 | 0.89 | IGF1R (0.80) | IGF1RKCNH2INSRPKN1RET | |
| SCHEMBL9950583 | 0.89 | IGF1R (0.80) | IGF1RKCNH2INSRPKN1RET | |
| SCHEMBL12496671 | 0.88 | IGF1R (1.00) | IGF1RKCNH2INSRPKN1RET | |
| SCHEMBL12496674 | 0.88 | IGF1R (1.00) | IGF1RKCNH2INSRPKN1RET | |
| SCHEMBL1443671 | 0.88 | IGF1R (0.79) | IGF1RKCNH2INSRPKN1RET | |
| SCHEMBL1443673 | 0.88 | IGF1R (0.79) | IGF1RKCNH2INSRPKN1RET | |
| SCHEMBL1443677 | 0.88 | IGF1R (0.79) | IGF1RKCNH2INSRPKN1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | NOVARTIS AG (CH) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | ETV6, CYP11B2, CYP11B1 | IGF1R 2735/4885KCNH2 3657/4885INSR 695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.