Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.64 |
| ▸ | RAF1 | P04049 | 5/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18804908 | 0.92 | BRAF (0.64) | BRAFMAPK14RAF1RXFP1KDR | |
| SCHEMBL9952854 | 0.91 | RAF1 (0.53) | BRAFMAPK14RAF1RXFP1KDR | |
| SCHEMBL9952826 | 0.91 | LMNA (0.54) | BRAFMAPK14RAF1RXFP1ALDH1A1 | |
| SCHEMBL9952360 | 0.90 | LMNA (0.51) | BRAFMAPK14RAF1RXFP1HTR2A | |
| SCHEMBL22572026 | 0.89 | LMNA (0.50) | BRAFMAPK14RAF1ALDH1A1LMNA | |
| SCHEMBL25743072 | 0.88 | KDR (0.54) | BRAFMAPK14RXFP1KDRHTR2A | |
| SCHEMBL22339738 | 0.85 | LMNA (0.57) | KDRALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL10067171 | 0.85 | LMNA (0.53) | KDRALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL22339327 | 0.84 | LMNA (0.54) | BRAFRAF1RXFP1KDRALDH1A1 | |
| SCHEMBL22339732 | 0.84 | LMNA (0.52) | RAF1KDRALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230165813-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2023-06-01 | — | — | US | disclosed |
| CN-106432137-B | Histone acetyltransferase modulators and uses thereof | 纽约市哥伦比亚大学理事会 | 2020-11-06 | — | — | CN | disclosed |
| US-20200330410-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2020-10-22 | — | — | US | disclosed |
| EP-3323813-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | UNIV COLUMBIA (US) | 2020-08-26 | — | — | EP | disclosed |
| EP-3323813-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | UNIV COLUMBIA (US) | 2020-08-26 | — | — | EP | disclosed |
| US-10653648-B2 | Histone acetyltransferase activators and compositions and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-05-19 | — | — | US | disclosed |
| US-20180244603-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2018-08-30 | — | — | US | disclosed |
| EP-3323813-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2018-05-23 | — | — | EP | disclosed |
| EP-3323813-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2018-05-23 | — | — | EP | disclosed |
| US-9969677-B2 | Histone acetyltransferase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-15 | — | — | US | disclosed |
| US-9969677-B2 | Histone acetyltransferase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-15 | — | — | US | disclosed |
| EP-2654428-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | UNIV COLUMBIA (US) | 2018-02-14 | — | — | EP | disclosed |
| EP-2654428-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | UNIV COLUMBIA (US) | 2018-02-14 | — | — | EP | disclosed |
| US-20180021273-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-01-25 | — | — | US | disclosed |
| WO-2018017858-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-01-25 | — | — | WO | disclosed |
| US-20170121276-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-05-04 | — | — | US | disclosed |
| US-20170121276-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-05-04 | — | — | US | disclosed |
| EP-2654428-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | The Trustees of Columbia University in the City of New York (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012088420-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012088420-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180021273-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | BRAF 2396/4885MAPK14 2273/4885RAF1 2684/4885 |
| US-20180244603-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | EP300, HTT, KAT2A | BRAF 3541/4885MAPK14 2899/4885RAF1 3877/4885 |
| US-20170121276-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | EP300, KAT2A, HTT | BRAF 3509/4885MAPK14 2840/4885RAF1 3893/4885 |
| US-20200330410-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | BRAF 2396/4885MAPK14 2273/4885RAF1 2684/4885 |
| US-10653648-B2 | Histone acetyltransferase activators and compositions and uses thereof | HDAC6, HDAC9, HDAC5 | BRAF 2396/4885MAPK14 2273/4885RAF1 2684/4885 |
| US-20230165813-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | BRAF 2396/4885MAPK14 2273/4885RAF1 2684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.