Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.30 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9953058 | 0.99 | PIK3CD (0.36) | PIK3CDPIK3CGPTGS2GPR55PRMT5 | |
| SCHEMBL9929356 | 0.82 | PIK3CD (0.42) | PIK3CDPIK3CGPTGS2GPR55PRMT5 | |
| Hydrochloric Acid SCHEMBL9928961 | 0.82 | PIK3CD (0.42) | PIK3CDPIK3CGPTGS2GPR55PRMT5 | |
| SCHEMBL9928787 | 0.80 | PIK3C3 (0.38) | PIK3CDPIK3CGPTGS2GPR55CYP2C9 | |
| SCHEMBL9953057 | 0.80 | PIK3CD (0.44) | PIK3CDPIK3CG | |
| SCHEMBL9952178 | 0.78 | PIK3CD (0.42) | PIK3CDPIK3CGPRMT5WDR77CYP2C9 | |
| SCHEMBL12813269 | 0.78 | PIK3CD (0.49) | PIK3CDPIK3CGPTGS2PRMT5WDR77 | |
| SCHEMBL19571043 | 0.78 | PIK3CD (0.39) | PIK3CDPIK3CGPTGS2GPR55CYP2C9 | |
| SCHEMBL9929160 | 0.76 | PIK3CD (0.44) | PIK3CDPIK3CGGPR55CYP2C9PIK3CB | |
| SCHEMBL9952021 | 0.74 | PIK3CG (0.36) | PIK3CDPIK3CGPTGS2GPR55PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |