Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | JUN | P05412 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RPS27 | P42677 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9929127 | 0.83 | PIK3CD (0.47) | PIK3CDMAPK8MAPK1DYRK3PRKD3 | |
| Hydrochloric Acid SCHEMBL9929064 | 0.82 | PIK3CD (0.46) | PIK3CDMAPK8MAPK1DYRK3PRKD3 | |
| SCHEMBL9952981 | 0.80 | PIK3CD (0.43) | PIK3CD | |
| SCHEMBL17138387 | 0.79 | PIK3CD (0.43) | PIK3CDMAPK8MAPK1DYRK3PRKD3 | |
| SCHEMBL9952024 | 0.78 | PIK3CD (0.37) | PIK3CDPRMT5WDR77CYP11B2CYP2C9 | |
| SCHEMBL9929636 | 0.77 | PIK3CD (0.47) | PIK3CDMAPK8MAPK1DYRK3PRKD3 | |
| Hydrochloric Acid SCHEMBL9953058 | 0.77 | PIK3CD (0.36) | PIK3CDPRMT5WDR77CYP11B2CYP2C9 | |
| SCHEMBL9951984 | 0.77 | PIK3CD (0.44) | PIK3CDMAPK8MAPK1DYRK3PRKD3 | |
| SCHEMBL9952919 | 0.76 | PIK3CD (0.41) | PIK3CDMAPK8MAPK1DYRK3PRKD3 | |
| SCHEMBL9953064 | 0.74 | PIK3CD (0.40) | PIK3CDMAPK8MAPK1DYRK3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |