Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 10/20 | 0.38 |
| ▸ | CNR2 | P34972 | 10/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954226 | 0.89 | PIK3CD (0.36) | PIK3CDMTORBRD4 | |
| SCHEMBL9953812 | 0.89 | PIK3CD (0.37) | PIK3CD | |
| SCHEMBL9952281 | 0.87 | CYP1A2 (0.37) | PIK3CDPIK3CAMTOR | |
| SCHEMBL21986430 | 0.86 | MTOR (0.38) | PIK3CDPIK3CAMTOR | |
| SCHEMBL9952369 | 0.86 | FYN (0.39) | PIK3CDTTK | |
| SCHEMBL9928776 | 0.85 | PIK3CD (0.48) | CNR1CNR2PIK3CDBRD4 | |
| SCHEMBL9953050 | 0.84 | PIK3CD (0.39) | PIK3CD | |
| SCHEMBL9952102 | 0.84 | PIK3CD (0.37) | PIK3CD | |
| SCHEMBL21986437 | 0.84 | LRRK2 (0.39) | PIK3CAMTOR | |
| SCHEMBL9952628 | 0.83 | PIK3CD (0.38) | PIK3CDPIK3CAMTORBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |