Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | BTK | Q06187 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 2/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21986431 | 0.89 | BTK (0.40) | MAPK14BTKNPC1TTKKMT2A | |
| SCHEMBL9952091 | 0.86 | CNR1 (0.38) | PIK3CDTTK | |
| SCHEMBL9952453 | 0.85 | PIK3CD (0.42) | PIK3CDCYP2C9LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL9952100 | 0.85 | PIK3CD (0.42) | PIK3CDCYP2C9LMNAKMT2AHPGD | |
| SCHEMBL9929099 | 0.83 | PIK3CD (0.54) | FYNPIK3CDMAPK14BTKLRRK2 | |
| SCHEMBL9952628 | 0.83 | PIK3CD (0.38) | PIK3CDCYP2C9LMNAKMT2AHPGD | |
| SCHEMBL9952812 | 0.82 | PIK3CD (0.40) | PIK3CDCYP2C9LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL9952102 | 0.81 | PIK3CD (0.37) | PIK3CDCYP2C9LMNASMN1; SMN2 | |
| SCHEMBL9953812 | 0.81 | PIK3CD (0.37) | PIK3CDCYP2C9LMNAKMT2AHPGD | |
| SCHEMBL21986432 | 0.81 | PIK3CD (0.37) | PIK3CDKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |