Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | JAK1 | P23458 | 4/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953488 | 0.94 | JAK2 (0.38) | JAK2JAK1CHRM4TYK2JAK3 | |
| SCHEMBL9929111 | 0.85 | PIK3CD (0.41) | JAK2JAK1CHRM4TYK2JAK3 | |
| SCHEMBL9960484 | 0.84 | PIK3CD (0.35) | PIK3CDSMN1; SMN2 | |
| SCHEMBL9929366 | 0.81 | PIK3CD (0.48) | JAK2JAK1TYK2JAK3PIK3CD | |
| SCHEMBL9952322 | 0.81 | SMN1; SMN2 (0.38) | JAK2JAK1CHRM4USP30SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9952456 | 0.81 | SMN1; SMN2 (0.37) | JAK2JAK1CHRM4USP30SMN1; SMN2 | |
| SCHEMBL14742531 | 0.81 | SMN1; SMN2 (0.38) | JAK2JAK1USP30ENPP2SMN1; SMN2 | |
| SCHEMBL14742321 | 0.81 | SMN1; SMN2 (0.38) | JAK2JAK1USP30ENPP2SMN1; SMN2 | |
| SCHEMBL9952900 | 0.80 | PIK3CD (0.34) | PIK3CDSMN1; SMN2 | |
| SCHEMBL9954419 | 0.79 | PDE4B (0.41) | CHRM4ENPP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |