Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952858 | 0.93 | PDE4B (0.44) | PDE4BSYKKLK7KLK5IDO1 | |
| SCHEMBL14742531 | 0.86 | SMN1; SMN2 (0.38) | PDE4BSMN1; SMN2SIGMAR1ENPP2 | |
| SCHEMBL14742321 | 0.86 | SMN1; SMN2 (0.38) | PDE4BSMN1; SMN2SIGMAR1ENPP2 | |
| SCHEMBL9952322 | 0.85 | SMN1; SMN2 (0.38) | PDE4BSMN1; SMN2SIGMAR1CHRM4 | |
| Hydrochloric Acid SCHEMBL9952456 | 0.84 | SMN1; SMN2 (0.37) | PDE4BSMN1; SMN2SIGMAR1CHRM4 | |
| SCHEMBL9928806 | 0.84 | PDE4B (0.42) | PDE4BSYKKLK7KLK5P2RY12 | |
| SCHEMBL9952153 | 0.79 | JAK2 (0.37) | SMN1; SMN2ENPP2CHRM4 | |
| SCHEMBL9929014 | 0.79 | PRMT5 (0.39) | PDE4BSMN1; SMN2SIGMAR1 | |
| SCHEMBL9929328 | 0.79 | PDE4B (0.44) | PDE4BSYKKLK7KLK5ITGB3 | |
| SCHEMBL14735982 | 0.78 | PDE4B (0.41) | PDE4BSMN1; SMN2SIGMAR1P2RY12CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |