Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.39 |
| ▸ | CDK2 | P24941 | 5/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.37 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9929706 | 0.86 | PIK3CD (0.45) | CYP1A2HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9952246 | 0.81 | CYP1A2 (0.51) | CYP1A2HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9953053 | 0.80 | CYP1A2 (0.51) | CYP1A2HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9952059 | 0.76 | NPC1 (0.51) | CYP1A2HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9952469 | 0.76 | CYP1A2 (0.51) | CYP1A2HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9952305 | 0.76 | CYP1A2 (0.52) | CYP1A2HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9952977 | 0.75 | CYP1A2 (0.47) | CYP1A2HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9953435 | 0.74 | CYP1A2 (0.51) | CYP1A2HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9952460 | 0.74 | NPC1 (0.50) | CYP1A2HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9952249 | 0.73 | HCRTR1 (0.38) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |