Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 4/20 | 0.33 |
| ▸ | AKT2 | P31751 | 4/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | ADK | P55263 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953071 | 1.00 | DHODH (0.33) | DHODHAKT1AKT2HIF1AGPR84 | |
| SCHEMBL9068281 | 0.77 | DHODH (0.40) | DHODHAKT1AKT2GPR84ADK | |
| SCHEMBL9953062 | 0.74 | PIK3CG (0.37) | DHODHPIK3CD | |
| SCHEMBL10080210 | 0.74 | PIK3CG (0.37) | DHODHPIK3CD | |
| SCHEMBL15302654 | 0.74 | PIK3CG (0.37) | DHODHPIK3CD | |
| SCHEMBL9953697 | 0.74 | DHODH (0.45) | DHODHAKT1AKT2SUCNR1 | |
| SCHEMBL30724619 | 0.74 | DHODH (0.45) | DHODHAKT1AKT2SUCNR1 | |
| SCHEMBL9959766 | 0.73 | DHODH (0.35) | DHODH | |
| SCHEMBL2721580 | 0.69 | PIK3CD (0.33) | HIF1APIK3CD | |
| SCHEMBL23355293 | 0.69 | HTR2A (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655342-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087784-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2012-06-28 | — | — | WO | disclosed |