Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 5/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CCR9 | P51686 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22493463 | 0.79 | HTR2A (0.48) | HTR2AHTR2CSLC13A5KDM1AMAOA | |
| SCHEMBL17981892 | 0.71 | LOXL2 (0.44) | MTNR1ACYP3A4 | |
| SCHEMBL12093550 | 0.71 | SLC13A5 (0.51) | HTR2AHTR2CSLC13A5KDM1AMAOA | |
| SCHEMBL21848099 | 0.71 | SIGMAR1 (0.33) | — | |
| SCHEMBL22383611 | 0.70 | HTT (0.46) | — | |
| SCHEMBL5780541 | 0.70 | SLC13A5 (0.54) | HTR2AHTR2CSLC13A5KDM1AMAOA | |
| SCHEMBL12776098 | 0.70 | SLC13A5 (0.47) | HTR2AHTR2CSLC13A5KDM1AMAOA | |
| SCHEMBL3055288 | 0.70 | TAAR1 (0.52) | HTR2AHTR2CSLC13A5KDM1AMAOA | |
| SCHEMBL18892461 | 0.70 | SLC13A5 (0.50) | HTR2AHTR2CSLC13A5KDM1AMAOA | |
| SCHEMBL28199240 | 0.70 | SLC13A5 (0.50) | HTR2AHTR2CSLC13A5KDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820860-A1 | PYRIDAZINE COMPOUNDS FOR INHIBITING NAV1.8 | Lieber Institute, Inc. (US) | 2021-05-19 | — | — | EP | disclosed |