Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.30 |
| ▸ | MERTK | Q12866 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RPS27 | P42677 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952062 | 0.90 | PIK3CD (0.37) | PIK3CDAXLMERTK | |
| SCHEMBL9952900 | 0.88 | PIK3CD (0.34) | PIK3CDHTT | |
| Trifluoroacetic Acid SCHEMBL9953549 | 0.84 | PIK3CD (0.35) | PIK3CDAXLMERTK | |
| Trifluoroacetic Acid SCHEMBL9952183 | 0.82 | PIK3CD (0.37) | PIK3CDAXLMERTK | |
| SCHEMBL9929305 | 0.82 | PIK3CD (0.43) | PIK3CDAXLMERTK | |
| SCHEMBL9953144 | 0.81 | PDE5A (0.35) | HTT | |
| SCHEMBL9953231 | 0.80 | PIK3CD (0.36) | PIK3CDHTT | |
| SCHEMBL9960484 | 0.79 | PIK3CD (0.35) | PIK3CDHTT | |
| SCHEMBL9951931 | 0.76 | PIK3CD (0.31) | PIK3CDAXLMERTK | |
| Trifluoroacetic Acid SCHEMBL9953150 | 0.75 | PIK3CD (0.33) | PIK3CDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |