Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPS1 | P31327 | 17/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9929056 | 0.86 | CPS1 (0.39) | CPS1 | |
| SCHEMBL9953797 | 0.81 | PARP10 (0.39) | MEN1NPC1KMT2AATML3MBTL1 | |
| SCHEMBL9952300 | 0.75 | NEK1 (0.35) | L3MBTL1 | |
| SCHEMBL9929240 | 0.74 | PIK3CD (0.46) | — | |
| SCHEMBL10278654 | 0.74 | CPS1 (0.39) | CPS1 | |
| SCHEMBL21986430 | 0.69 | MTOR (0.38) | CPS1KMT2A | |
| SCHEMBL9952917 | 0.68 | FASN (0.33) | KDM1A | |
| SCHEMBL21986437 | 0.68 | LRRK2 (0.39) | — | |
| SCHEMBL9928941 | 0.66 | NPC1 (0.41) | MEN1NPC1KMT2AATML3MBTL1 | |
| SCHEMBL9928829 | 0.66 | MEN1 (0.37) | MEN1NPC1KMT2AATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |