Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NEK1 | Q96PY6 | 3/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952300 | 0.91 | NEK1 (0.35) | L3MBTL1NEK1IMPDH2TAAR1HTR2A | |
| SCHEMBL9928829 | 0.83 | MEN1 (0.37) | PARP10PARP14MEN1NPC1KMT2A | |
| SCHEMBL9953181 | 0.81 | CPS1 (0.37) | MEN1NPC1KMT2AATML3MBTL1 | |
| SCHEMBL9929229 | 0.80 | PIK3CD (0.38) | PARP10PARP14MEN1NPC1KMT2A | |
| SCHEMBL9953812 | 0.79 | PIK3CD (0.37) | PARP10PARP14MEN1KMT2A | |
| SCHEMBL9928849 | 0.74 | CASP1 (0.37) | NPC1ACLYCASP1 | |
| SCHEMBL9929271 | 0.73 | ACLY (0.41) | MEN1NPC1KMT2AATML3MBTL1 | |
| Hydrochloric Acid SCHEMBL17337368 | 0.72 | PIK3CD (0.53) | — | |
| SCHEMBL9928941 | 0.72 | NPC1 (0.41) | MEN1NPC1KMT2AATML3MBTL1 | |
| SCHEMBL9928968 | 0.72 | PIK3CD (0.38) | CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |