Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL855488 | 0.88 | HSD17B10 (0.48) | NPC1ALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL732352 | 0.83 | NPC1 (0.52) | NPC1ALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL855484 | 0.81 | NPC1 (0.54) | NPC1ALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL741345 | 0.78 | HSD17B10 (0.46) | NPC1ALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL857446 | 0.78 | NPC1 (0.56) | NPC1ALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL27878220 | 0.77 | PLA2G1B (0.50) | NPC1ALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL858850 | 0.76 | NPC1 (0.59) | NPC1ALDH1A1LMNAKDM4EHSD17B10 | |
| SCHEMBL393051 | 0.75 | KMT2A (0.57) | NPC1ALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL10694208 | 0.75 | TSHR (0.54) | TSHRALDH1A1LMNAKDM4EHSD17B10 | |
| SCHEMBL9955673 | 0.75 | KDM4E (0.46) | NPC1ALDH1A1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |