Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 13/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.47 |
| ▸ | CASP1 | P29466 | 6/20 | 0.47 |
| ▸ | CASP7 | P55210 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | USP2 | O75604 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953490 | 0.84 | PI4KA (0.65) | PI4KAPIK3CGALDH1A1CYP1A2CASP1 | |
| SCHEMBL9953522 | 0.81 | PI4KA (0.73) | PI4KAPIK3CGCASP1 | |
| SCHEMBL10288670 | 0.81 | PI4KA (0.57) | PI4KAPIK3CGALDH1A1LMNA | |
| SCHEMBL10288673 | 0.80 | PI4KA (0.56) | PI4KAPIK3CGCYP3A4 | |
| SCHEMBL9955010 | 0.80 | PI4KA (0.59) | PI4KAPIK3CGALDH1A1LMNA | |
| SCHEMBL9954494 | 0.80 | PI4KA (0.63) | PI4KAPIK3CG | |
| SCHEMBL9954698 | 0.78 | PI4KA (0.72) | PI4KAPIK3CG | |
| SCHEMBL9953082 | 0.78 | PI4KA (0.70) | PI4KAPIK3CG | |
| SCHEMBL10288761 | 0.77 | PI4KA (0.57) | PI4KAPIK3CGALDH1A1LMNA | |
| SCHEMBL9954452 | 0.77 | PI4KA (0.69) | PI4KAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |