Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | BTK | Q06187 | 6/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952078 | 0.80 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL9929201 | 0.79 | PIK3CD (0.43) | PIK3CDBTKMAPK14 | |
| SCHEMBL9929099 | 0.77 | PIK3CD (0.54) | PIK3CDBTKMAPK14 | |
| SCHEMBL9961003 | 0.77 | PIK3CD (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL21486193 | 0.77 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL9929795 | 0.75 | PIK3CD (0.43) | PIK3CDBTKPIK3CAPIK3CBMAPK14 | |
| SCHEMBL9928776 | 0.73 | PIK3CD (0.48) | PIK3CDCNR1CNR2 | |
| SCHEMBL9929413 | 0.73 | MAPK14 (0.40) | BTKMAPK14 | |
| SCHEMBL9929153 | 0.68 | PIK3CD (0.55) | PIK3CDPIK3CBPIK3CG | |
| SCHEMBL9953267 | 0.68 | PIK3CD (0.35) | PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |