Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21486193 | 0.81 | PIK3CD (0.42) | PIK3CDPIK3CBPIK3CAPIK3CGEGFR | |
| SCHEMBL9960830 | 0.81 | PIK3CD (0.35) | PIK3CDPIK3CBPIK3CAPIK3CGLMNA | |
| SCHEMBL9953754 | 0.80 | PIK3CD (0.35) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL9928850 | 0.76 | PIK3CD (0.63) | PIK3CDPIK3CBPIK3CAEGFR | |
| SCHEMBL9961003 | 0.74 | PIK3CD (0.41) | PIK3CDPIK3CBPIK3CAPIK3CGEGFR | |
| SCHEMBL9928912 | 0.73 | PIK3CD (0.78) | PIK3CDEGFR | |
| SCHEMBL2717116 | 0.73 | PIK3CD (0.70) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL3772557 | 0.73 | PIK3CD (0.70) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL2717587 | 0.73 | PIK3CD (0.51) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL3781552 | 0.73 | PIK3CD (0.70) | PIK3CDPIK3CBPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |