Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952915 | 0.95 | PDE5A (0.31) | PDE5AMAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL9952126 | 0.91 | PDE5A (0.33) | PDE5AMAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL9952734 | 0.88 | HTT (0.35) | PDE5AEGFRMAPTTSHRHTT | |
| SCHEMBL9952079 | 0.86 | PDE5A (0.32) | PDE5AMAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL9960517 | 0.85 | PDE5A (0.31) | PDE5AMAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL9952416 | 0.85 | PDE5A (0.33) | PDE5AMAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL9953144 | 0.84 | PDE5A (0.35) | PDE5AMAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL9928998 | 0.83 | PIK3CD (0.41) | EGFR | |
| Trifluoroacetic Acid SCHEMBL9960946 | 0.83 | PDE11A (0.32) | — | |
| SCHEMBL9960535 | 0.83 | PDE5A (0.32) | PDE5AMAPTTSHRHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |